What is the basis for the difference in how the leading and lagging strands of DNA molecules are synthesized?

The origins of replication occur only at the 5' end.

Helicases and single-strand binding proteins work at the 5' end.

DNA ligase works only in the 3' 鈫?5' direction.

DNA polymerase can join new nucleotides only to the 3' end of a growing strand.

Polymerase can work on only one strand at a time.What is the basis for the difference in how the leading and lagging strands of DNA molecules are synthesized?
DNA polymerases can join new nucleotides only to the 3' end of a growing strandWhat is the basis for the difference in how the leading and lagging strands of DNA molecules are synthesized?
Leading strand is synthesized in the 5' to 3' direction continously where as the lagging strand is synthesized in fragments called the okazaki fragments. This is due to the fact the the lagging strand is in the 3'-5' direction, therefore polymerase III only synthesizes up to a certain point i.e; it reaches the primer then it must break away, once this occurs the DNA strand zips back and polymerase III re-attaches and replication continues.



From the choices you've given above ( sry didn't notice them before) the correct answer would be the 4th one.

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